Research Study
CurQfen® delivers the bioactive free unconjugated curcumin into brain and other organ tissues in addition to its enhanced plasma bioavailability
Absorption and organ tissue distribution of the bioactive form of any substance is very crucial for the functional benefits/therapeutic efficacy at the target site. While most of the formulations of curcumin deliver the conjugated metabolites of curcumin in plasma with no evidence of tissue distribution, CurQfen® has been shown to deliver significantly high levels of free unconjugated curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) into the brain and other organ tissues, in addition to its 25-fold enhancement in plasma bioavailability. Well-designed UPLC-ESI-MS/MS study, conducted as per ICH guidelines, was recently published in the Journal of Functional Food, indicating its importance in the light of the recent study that the major metabolites of curcumin, namely, mono and di-glucuronides, possess no anti-proliferative and anti-inflammatory effects.
